Another fun, possibly stupid, possibly brutal barb PvE build
The whole idea is using chaos as your crowd control. Cleave, Ground Stomp and Leap Attack are all runed to throw enemies around and knock them into each other. So you'll be perpetually blasting enemies all over the screen, knocking them into each other (for damage). The domino effect of enemies blasting into other enemies should, in theory, interrupt casters and ranged enemies.
Then, I have the Ancient Spear + Hammer of the Ancients combo to pick off single targets and burn them down quickly. AS is runed for +fury so I have enough juice to burn single targets down quickly with HotA runed for +400% damage.
Crit is important to this build to trigger the Scattering Blast rune on Cleave, as well as high crit chance for single target HotA burns. The build is a bit low on defense, with the idea that enemies will be bouncing around all over the place instead of attacking.
This build might have problems with boss fights, but there's Ignore Pain with the +healing mod, pop that and crit a few times with HotA, add the +10% life steal from Bloodthirst passive, and it could very well be viable.