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Quote from speedloader1

Currently, I think the best solo builds are the invincible Shi Mizu's ZHPS monks.

http://us.battle.net/d3/en/item/shi-mizus-haori
Core skills http://us.battle.net/d3/en/calculator/monk#..g.Th!VT!..Y.YZ
You absolutely need 69% CDR and no heals/pickup radius at all to make it work.
With 69% CDR you can alternate between SSS and Serenity without interruption. Since nothing can hurt you anymore, you can play at 20-25% HPs with minimal toughness and benefit from shi mizu's 100% CHC all the time.

If ever you take a health globe, use Divine Protection to return below 20-25% hp, NDE secures the procedure.

There are many ways to abuse such mechanisms, critical hits related skills - cyclone (fill the whole screen wooo..), numbing light, eventually sixth sense (+ Backlash if you don't need Divine Protection) , and many items, the most obvious being http://us.battle.net/d3/en/item/irontoe-mudsputters and http://us.battle.net/d3/en/item/prides-fall-pgClp .. also consider using wyrdward and Epiphany - Ascendance..